How long will it take:
The CIT protocol takes 1 ½ - 2 hours in the clinic.
There is a 30 min wait in between injections and a 1 hour wait after the last
You can do CIT up to 2 times a week, with 48 hours in between each CIT
What to bring on the day of the visit:
Books, activities, laptop, etc.
Wear a half sleeve or sleeveless shirt
Have a light breakfast the morning of the procedure
Have a light snack before the procedure
What we will do the day of the visit:
Make sure your asthma, if present, is under good control.
Obtain baseline spirometry - FEV1 above 70%
No B-blockers, ACEI, or evidence of cardiovascular disease
Ensure we have Informed consent in chart
What happens after CIT:
For most patients, the final dose received during CIT will be repeated for the
first post-CIT injection the week after.
For patients who experienced a systemic reaction during CIT, the first post-CIT
dose will be lowered.
Following CIT, the regular IT schedule will be followed going forward
Generally if you tolerate the whole protocol you will continue on weekly
injections for another 3-4 weeks, then we can proceed to every other week
shots, followed by every 3 week shots, then monthly
We can identify allergens by performing blood tests or skin tests.
What is Cluster Immunotherapy (CIT)? Cluster immunotherapy is a method for rapidly desensitizing patients to inhalant allergens. Our cluster protocol involves giving a person multiple allergy injections over several hours over several days, achieving a near-maintenance dose in a very short amount of time. In this way you can do a year's worth of allergy shots in 3-6 weeks! The procedure involves 2-3 rounds of allergy injections, with incremental increases in dose, which are given in a span of 1.5 to 3 hours. After CIT, a person comes into the allergist’s office once a week for the next several weeks. Then we will start spacing out the frequency of your injections according to our immunotherapy (IT) protocol.
Any drawbacks or risks of Cluster Immunotherapy? Risk of anaphylaxis (severe allergic reaction) to slightly more than traditional schedules but less than rush protocols. We reduce this risk with a specially designed medication regimen that you take before the procedure Premedication with anti-leukotriene’s (montelukast) and antihistamines has been shown to decrease the incidence of systemic reactions with CIT significantly May not be covered by all insurance companies, thus cost may be higher Still requires you to continue medication during the build-up phase
Advantages of Cluster Immunotherapy?
More rapid clinical improvement with fewer visits for injections
Allows the patient to achieve maintenance dose more rapidly
Allows the patient to reach monthly maintenance injections quicker
Local reactions (swelling, itching, or tenderness at the injection sites)
Systemic reaction, which may include:
Hives, itchy eyes, nose or throat, runny nose, nasal congestion, sneezing
Tightness in chest and or throat, coughing and or wheezing
Nausea and vomiting, abdominal cramps
Lightheadedness or faintness and possibly shock
Premedication 1 day prior and the morning of the procedure.
Histamine (H1) Blocker: Options include Claritin 10 mg, or Zyrtec 10 mg, or Allegra 180 mg once a day, Montelukast (Singulair) 10 mg once a day.
Take both pills at the same time each day if possible
Day 1 – Day before CIT Premedication Time
Day 2 – Day OF CIT Premedication Time, 8AM
Our physicians will combine an in-depth interview, environmental exposure history, and physical examination together with specific laboratory tests to help arrive at a diagnosis. Common allergy tests performed in an allergist’s office include allergen skin testing and spirometry which is a test to measure lung function. One of our allergists will provide individualized treatment plans focusing on environmental avoidance measures and prevention in addition to medical treatment. Allergists are especially recognized for being the expert provider of allergen immunotherapy (allergy shots and sublingual drops). Allergen immunotherapy is the only active intervention that can alleviate allergy or asthma symptoms without the use of medications.
What are allergies?
Allergies are the result of your body’s immune system having a heightened sensitivity resulting in reactions to foreign substances that are otherwise harmless. These substances include pollens (trees, grasses and weeds), animal dander and saliva (cats and dogs), mold spores, dust mites, cockroaches, foods, and medications.
Under normal conditions, your immune system would only react if being threatened by harm from pathogens such as bacteria, viruses, fungi, parasites or cancers. However, those who suffer from allergies often experience specific symptoms triggered as your immune system reacts to those harmless substances. Depending on the severity of the allergic reaction, the symptoms can be relatively tolerable or excruciatingly unbearable.
Greater Austin Allergy, Asthma & Immunology, PLLC
Call Us: (512) 732-2774
How can you treat allergies once you’ve identified them? We can discuss hygiene and avoidance measures that will decrease the burden posed by the allergen on your body. When these measures aren’t enough, we discuss treatment options with medications, allergy shots and allergy drops. For Patients doing allergy shots, we offer traditional, rush and cluster protocols to build up to the maintenance dose. Most patients, when presented with the options of the various dosing schedules, choose cluster protocol immunotherapy because it offers fewer visits and faster results compared to traditional schedules and a better safety profile than rush schedules.
As an asthma specialist, we understand how hard it can be to live with asthma. We want to help you to find a better way.
Our clinics in the Austin, TX area are devoted to helping patients with allergies and asthma to improve their quality of life. Call today to find out what we can do for you!